Fig. 2

PGRN deficiency induces FTD-like behaviors. A PGRN deficiency decreased the recognition index relative to WT control group in novel object recognition test. B PGRN deficiency did not change the alteration triplet in the Y maze, compared to WT mice. C Compared with WT mice, PGRN deficiency in mice had no effects on the latency the platform, but its deficiency decreased the platform site crossings, time in the target quadrant and time in the target in morris water maze test. D PGRN deficiency decreased social interaction changes in both same sex and different sex, compared to WT mice. E PGRN deficiency in mice were disinhibited due to they spent more time and numbers in open arms than their WT littermates in the elevated plus maze test. n = 8 per group. Data were analyzed by Student's t-test, and expressed as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ns not significant