Fig. 7

Co-culturing with Aβ-exposed astrocytes decreases neuronal synaptic activity. A The frequency of sEPSCs was significantly decreased in Aβ co-cultures. B No difference was detected in the amplitude of sEPSCs. D A similar decrease was also observed in the Aβ co-culture frequency of mEPSCs. E There was no difference in the amplitude of mEPSCs in control co-cultures compared to Aβ co-cultures. C, F Representative traces of gap-free recordings. Red arrowheads indicate the position of sEPSCs and mEPSCs, respectively. (Results are presented as mean ± S.E.M.; neurons + astrocytes: n = 9 cells out of one batch, neurons + Aβ astrocytes: n = 13 cells out of one batch; **p < 0.01)