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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Extracellular vesicles from mesenchymal stem cells reduce neuroinflammation in hippocampus and restore cognitive function in hyperammonemic rats

Fig. 6

Incubation with EVs from MSCs reverses microglial and astrocytic activation in hippocampal slices from hyperammonemic rats. Representative images of A immunohistochemistry against Iba-1 and B GFAP in hippocampus. C Area of Iba1 stained cells (n = 5–8) and D percentage of area stained with GFAP, expressed as percentage of controls, (n = 5–9) in hippocampus. One-way ANOVA with Tukey post hoc test was performed to compare all groups. Values are the mean ± SEM. Values significantly different from controls are indicated by asterisk (*p < 0.05, **p < 0.01), values significantly different from HA group are indicated by a (a = p < 0.05, aa = p < 0.01) and values significantly different from HA + EVs group are indicated by b (bb = p < 0.01; bbb = p < 0.001; bbbb = p < 0.0001). Sample size of each group is indicated at the bottom of the bars

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