Fig. 6From: Extracellular vesicles from mesenchymal stem cells reduce neuroinflammation in hippocampus and restore cognitive function in hyperammonemic ratsIncubation with EVs from MSCs reverses microglial and astrocytic activation in hippocampal slices from hyperammonemic rats. Representative images of A immunohistochemistry against Iba-1 and B GFAP in hippocampus. C Area of Iba1 stained cells (n = 5–8) and D percentage of area stained with GFAP, expressed as percentage of controls, (n = 5–9) in hippocampus. One-way ANOVA with Tukey post hoc test was performed to compare all groups. Values are the mean ± SEM. Values significantly different from controls are indicated by asterisk (*p < 0.05, **p < 0.01), values significantly different from HA group are indicated by a (a = p < 0.05, aa = p < 0.01) and values significantly different from HA + EVs group are indicated by b (bb = p < 0.01; bbb = p < 0.001; bbbb = p < 0.0001). Sample size of each group is indicated at the bottom of the barsBack to article page