Fig. 1

Effect of Abcc8 knockout (KO) on apparent diffusion coefficient (ADC) in brain after cecal ligation and puncture (CLP) in mice, as assessed by magnetic resonance imaging (MRI). On day 1 (A) and day 4 (B), after CLP, wild-type (WT) and Abcc8 KO mice underwent brain MRI (WT CLP (WCLP), KO CLP (KCLP)). Additional controls included shams (WT SHAM (WS), KO SHAM (KS)). Regions of interest (ROI) analysis was performed after manual delineation of a priori regions of the brain that include the cortex, hippocampus, and thalamus. Mean ADC values are depicted. Each graph represents the mean ADC value from a specific ROI. (*P < 0.05 vs. WS; ^# P < 0.05 vs. KCLP) P values were calculated by ANOVA, and error bars represent SEM) (sham n = 5, and CLP n = 10 for each timepoint)