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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Abcc8 (sulfonylurea receptor-1) knockout mice exhibit reduced axonal injury, cytotoxic edema and cognitive dysfunction vs. wild-type in a cecal ligation and puncture model of sepsis

Fig. 4

Effect of Abcc8 knockout (KO) on the microglial response in brain after cecal ligation and puncture (CLP) in mice, as assessed using ionized calcium-binding adaptor molecule-1 (Iba-1) immunohistochemistry. Representative micrographs of brain areas stained for Iba-1 in the regions of interest (ROI) of sham and CLP mice on day 1 after CLP. The quantification of activated microglia is shown in A. Illustrative micrographs demonstrate a significant increase in Iba-1 + microglial cells on day 1 after CLP (20 × magnification) in the cortex that was not seen in the Abcc8 KO (B). (*P < 0.05 vs. WS; # P < 0.05 vs. KCLP) P values were calculated by ANOVA, and error bars represent SEM) (sham n = 10, and CLP n = 15 for each timepoint)

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Journal of Neuroinflammation

ISSN: 1742-2094