Fig. 4

CUMS mice reduced hippocampal neurogenesis. a Comparison of microstructures of hippocampal CA3 and DG regions of mice in each group. b Immunofluorescence of PSD95, DCX and NeuN in hippocampal DG region of mice in each group. c Statistics on the number of PSD95 positive cells in the hippocampal DG area. d Statistics on the number of DCX positive cells in the hippocampal DG area. e Statistics on the number of NeuN positive cells in the hippocampal DG area. f mRNA levels of the DA expression in hippocampus. g mRNA levels of the NE expression in hippocampus. h mRNA levels of the BDNF expression in hippocampus. i mRNA levels of the PSD95 expression in hippocampus. j mRNA levels of the SYN expression in hippocampus. k mRNA levels of the MAO-A expression in hippocampus. l mRNA levels of the Lc3b expression in hippocampus. m mRNA levels of the p62 expression in hippocampus. n mRNA levels of the bcl-2 expression in hippocampus. Each value represents the mean ± SEM. *p < 0.05, **p < 0.01 and ***p < 0.001 means difference of WT Control vs. WT CUMS, TPH2 KO vs. TPH2 KO CUMS, TPH2 KO vs. WT CUMS + FLX at the same point