Fig. 5

Effects of CUMS on PI3K/Akt/mTOR and autophagy pathway in mice. a Electrophoretogram of ATG7, ATG5, P62, Bcl-2, Lc3, Beclin1 and β-actin protein in hippocampus by western blotting. b Data of relative expression of ATG7 protein. c Data of relative expression of ATG5 protein. d Data of relative expression of P62 protein. e Data of relative expression of Bcl-2 protein. f Data of relative expression of LC3 protein. g Data of relative expression of Beclin1 protein. h Electrophoretogram of p-PI3K, p-AKT, p-mTOR, SYN, PSD95, BDNF and β-actin protein in hippocampus by western blotting. i Data of relative expression of p-PI3K protein. j Data of relative expression of p-AKT protein. k Data of relative expression of p-mTOR protein. l Data of relative expression of SYN protein. m Data of relative expression of PSD95 protein. n Data of relative expression of BDNF protein. Each value represents the mean ± SEM. *p < 0.05, **p < 0.01 and ***p < 0.001 means difference of WT Control vs. WT CUMS, TPH2 KO vs. TPH2 KO CUMS, TPH2 KO vs. WT CUMS + FLX at the same point