Fig. 8

Composition of the colon microbiota. Relative contribution of the top 10 phyla in the WT Control, WT CUMS, TPH2 KO Control, TPH2 KO CUMS and WT CUMS + FLX groups in the colon. a Relative abundance of the top 22 genera in the Control, WT CUMS, TPH2 KO Control, TPH2 KO CUMS and WT CUMS + FLX groups in the colon. b Taxonomic cladogram obtained from LEfSe sequence analysis. c In the colon biomarker taxa are highlighted by coloured circles and shaded areas. The diameter of each circle reflects the abundance of that taxa in the community. d Taxa with a different abundance in the colon (n = 6). A cutoff value ≥ 2.0 was used for the linear discriminant analysis (LDA). WTC: WT Control, WTS: WT CUMS, KOC: TPH2 KO Control, KOS: TPH2 KO CUMS, Treat: WT CUMS + FLX