Fig. 4

Cytokine and chemokine concentrations in the CSF comparing MP4-immunized mice with or without B cell aggregates. The graphs display the cytokine and chemokine concentrations (pg/ml) in the CSF of MP4-immunized mice showing B cell aggregates (> 30 B cells) compared to mice without aggregation. Chemokines and cytokines with significant differences between the two groups are presented. Mean values ± SEM are shown.  *p < 0.05, unpaired t-test (normal distribution), Mann–Whitney test (no normal distribution), CCL C-C motif chemokine ligand, CXCL C-X-C motif chemokine ligand, SEM standard error of the mean