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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Neonatal inflammation increases hippocampal KCC2 expression through methylation-mediated TGF-β1 downregulation leading to impaired hippocampal cognitive function and synaptic plasticity in adult mice

Fig. 1

Blocking GABAergic transmission prevents the impairment of hippocampus-dependent memory in adult mice exposed to LPS during the neonatal period. CON and LPS represent control mice and mice neonatally treated with LPS (LPS mice), respectively. A Timeline of the experimental approach. B and C Quantification of context freezing (B) or cued freezing (C) of control mice and LPS mice treated with vehicle (VEH) or PTX in the fear conditioning. D Average latency (± s.e.m) to reach the hidden platform across training days of control mice and LPS mice treated with VEH or PTX in the hidden platform test of Morris water maze. E Quantification of time in the platform zone of control mice and LPS mice treated with VEH or PTX in the probe test of Morris water maze. F Quantification of the average swim speed of control mice and LPS mice treated with VEH or PTX in the probe test of Morris water maze. In B, C, E and F, circles indicate single data points and their averages (± s.e.m) are shown as columns. Statistical analysis: two-way ANOVA followed by Bonferroni in B, C, E and F, and three-way ANOVA followed by Bonferroni in D. **P < 0.01, ***P < 0.001 and ****P < 0.0001

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Journal of Neuroinflammation

ISSN: 1742-2094