Fig. 2

Blocking GABAergic synaptic transmission with GABA_AR antagonist PTX (10 μM) rescues the LTP failure in dorsal CA1 of adult mice neonatally treated with LPS. CON and LPS represent control mice and mice neonatally treated with LPS (LPS mice), respectively. A Timeline of the experimental approach for obtaining the results in B and C. B and C The comparison of morphological structure (B) and volume (C) of the dorsal hippocampus between control and LPS mice. B Scale bar = 500 μm. D Timeline of the experimental approach for obtaining the results in F–G. E Sketch of the in vitro recording configuration. F Left, the superimposition of the original fEPSPs waves recorded in each group at 15 min (solid line) pre-HFS and 60 min post-HFS (dotted line). Right, the average time course of the change in the fEPSPs slope (± s.e.m) in hippocampal slices from control and LPS mice during bath application of either VEH or PTX. ‘↓’ indicates the time of HFS delivery. G The comparison of the fEPSPs slope at 60 min post-HFS in each group recorded in F. In C and G, circles indicate single data points and their averages (± s.e.m) are shown as columns. Statistical analysis: Student’s t test in C, two-way ANOVA followed by Bonferroni in G. **P < 0.01