Fig. 3

There is a postsynaptic potentiation of GABAergic transmission in dorsal CA1 of adult mice neonatally treated with LPS. CON and LPS represent control mice and mice neonatally treated with LPS (LPS mice), respectively. A Timeline of the experimental approach. B Resting potential of pyramidal neurons from control and LPS mice. C Representative traces of spontaneous subthreshold activity in slices from control and LPS mice before and during bath application of bicuculline (BIC). D Cumulative amplitude distributions of mIPSCs in pyramidal neurons from control and LPS mice. E Average mIPSC amplitudes in pyramidal neurons from control and LPS mice. F Cumulative frequency distributions of mIPSCs in pyramidal neurons from control and LPS mice. G Average mIPSCs frequency in pyramidal neurons from control and LPS mice. H Average mIPSC rise time in pyramidal neurons from control and LPS mice. I Average mIPSC delay time in pyramidal neurons from control and LPS mice. In B, E and G–I, circles indicate single data points and their averages (± s.e.m) are shown as columns. Statistical analysis: Student’s t test in B, E and G–I, and Kolmogorov–Smirnov test in D and F. ****P < 0.0001