Fig. 7

TGF-β1 vector treatment restores the synaptic plasticity in the dorsal CA1 area and hippocampus-dependent memory in adult mice neonatally treated with LPS. CON and LPS represent control mice and mice neonatally treated with LPS (LPS mice), respectively. A Timeline of the experimental approach. B Quantification of synaptic plasticity at CA3–CA1 pathway in control and LPS mice treated with control vector or TGF-β1 vector. C Quantification of context freezing of control and LPS mice treated with control vector or TGF-β1 vector in the fear conditioning. D Average latency (± s.e.m) to reach the hidden platform across training days of control mice and LPS mice treated with control vector or TGF-β1 vector in the hidden platform test of Morris water maze. E Quantification of time in the platform zone of control and LPS mice treated with control vector or TGF-β1 vector in the probe test of Morris water maze. In B, C, and E, circles indicate single data points and their averages (± s.e.m) are shown as columns. Statistical analysis: two-way ANOVA followed by Bonferroni in B, C and E, and three-way ANOVA followed by Bonferroni in D. **P < 0.01, ***P < 0.001 and ****P < 0.0001