Fig. 6

RPE CD47-expression decreases with age and in intermediate AMD in humans. A Linear regression of the correlation of age to relative expression of Cd47 mRNA normalized with RPS26 expression in RPE mRNA preparations from 35 subjects older than 60 years determined by quantitative RT-PCR. The subjects had normal post-mortem fundus appearance and no known history of AMD or other retinal diseases (p = 0.0261 deviant from zero). B Linear regression of the correlation of age of Cd47 mRNA normalized with the average of 40 RPE gene expression in RPE/choroid mRNA preparations from control subjects (CTL n = 36; p = 0.0156 deviant from zero) and intermediate AMD patients (intAMD n = 18; p = 0.0704 deviant from zero) from the RPE/choroid transcription data set of [23]. C Cd47 mRNA normalized with the average of 40 RPE gene expression in RPE/choroid mRNA preparations from CTL subjects and intAMD patients in central (0-8 mm foveal distance) and peripheral (8–14 mm foveal distance) from the RPE/choroid transcription data set of [23] (*Mann–Whitney p = 0.0217)