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Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: Role of acyl-coenzyme A: cholesterol transferase 1 (ACAT1) in retinal neovascularization

Fig. 10

Inhibiting ACAT1 attenuates OGD-induced increases in expression of ACAT1 and inflammatory mediators in HMC3 microglia. Human microglial cells were subjected to OGD (1% O2, glucose-free medium) or normal media (21% O2, 25 mM glucose) with K604 or vehicle for 24 h. a Western blotting, and b–e quantification shows upregulation of MCSF (a, b), ACAT1 (a, c), and TREM1 (a, e) after hypoxia treatment as compared with normoxia. K604 treatment markedly suppressed all except VEGF (a, d). mean ± SEM, n = 6

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