Fig. 2

Cell type-specific inactivation of MAGL induces distinct gene expression profiles in microglia and astrocytes. A t-SNE plots of microglia and astrocytes clusters. Each colored dot represents a cell originated from WT, tKO, nKO or aKO mice. B Up- and down-regulated DEGs in microglia from different MAGL KO mice. C Up- and down-regulated DEGs in astrocytes from different MAGL KO mice. D, E The number of up- and down-regulated DEGs and their relationships in microglia and astrocytes from different genotypes. F, G Representative DEGs in microglia and astrocytes ***P < 0.0001 compared with WT; ^###P < 0.001 compared with tKO; ^§P < 0.05, ^§§§P < 0.001 compared with nKO