Fig. 5
From: Regulatory T cells decrease C3-positive reactive astrocytes in Alzheimer-like pathology
Depletion of Tregs affects the expression of several A1-like astrocytic markers. A, B Quantification of mRNA coding for the A1-like reactive astrocyte markers FKBP5, AMIGO2, H2D1 and SERPING1 in the brain of mice treated with either PBS or anti-CD25 antibody (A), or with either PBS or IL-2 (B). Values were first normalized according to the expression of the housekeeping gene PPIA and then normalized to the mean value of PBS-injected WT control group. Mean +/− SEM (from n = 5–6 mice/ group). Mann–Whitney test: *P < 0.05; **P < 0.01; ***P < 0.001