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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Patchouli alcohol attenuates the cognitive deficits in a transgenic mouse model of Alzheimer’s disease via modulating neuropathology and gut microbiota through suppressing C/EBPβ/AEP pathway

Fig. 4

Effects of PA on gut dysbiosis in TgCRND8 mice. A Effects of PA on α-diversity in TgCRND8 mice. Observed OUT represents the actual observed number of operational taxonomic units (OTUs). Good's coverage reflects the depth of sequencing. The closer the Good's coverage is to 1, the deeper the sequencing has covered all species in the sample. Chao1 and ACE estimate microbiota’s total richness, that is, the number of species observed in each sample. Shannon index estimates both the richness and evenness of the microbiota community and provides information about microbial diversity indexes; B PCoA of microbial community structure; C gut microbiota composition at the phylum level; D gut microbiota composition at the family level; E gut microbiota composition at the genus level. Data were expressed as the mean ± SEM (n = 6). #p < 0.05 and ##p < 0.01 compared with the WT group; *p < 0.05 and **p < 0.01 compared with the Tg + vehicle group

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