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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Patchouli alcohol attenuates the cognitive deficits in a transgenic mouse model of Alzheimer’s disease via modulating neuropathology and gut microbiota through suppressing C/EBPβ/AEP pathway

Fig. 6

Effects of PA on behavioral impairments, C/EBPβ/AEP signaling pathway and AD-like pathologies after the overexpression of C/EBPβ in the hippocampus of TgCRND8 mice. A Schematic representation of the AAV genome encoding the CEBP/β sequence under the control of the CMV promoter; B experimental design and treatment schedule for identifying the potential mechanisms underlying the effects of PA on the TgCRND8 mice; CL effects of PA (50 mg/kg) on behavioral impairments and cognitive deficits after the overexpression of C/EBPβ in the hippocampus of TgCRND8 mice (n = 8). C Representative images of the movement paths in OFT; D movement velocity in OFT; E distance traveled in OFT; F time spent in the center zone in OFT; G Recognition Index in NORT; H representative images of the swimming paths of mice in the MWMT probe test; I escape latency to platform during training days in MWMT; J numbers of the target crossing in the MWMT probe test; K the time spent in the target quadrant in the MWMT probe test; L swimming speed in the target quadrant in the MWMT probe test; M representative western blotting images and quantitative analysis of the protein expressions of C/EBPβ and AEP in the hippocampus (n = 3); N representative western blotting images and quantitative analysis of the protein expressions of hyperphosphorylated tau and Tau N368 in the hippocampus (n = 3); O40 and Aβ42 levels and Aβ42/Aβ40 ratio (n = 5). Data were expressed as the mean ± SEM (n = 3–8). #p < 0.05, ##p < 0.01 and ###p < 0.001 compared with the WT + OE-Control group; *p < 0.05, **p < 0.01 and ***p < 0.001 compared with the Tg + OE-Control group; p < 0.05, ▲▲p < 0.01 and ▲▲▲▲p < 0.0001 compared with the Tg + OE-C/EBPβ group

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