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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Siponimod ameliorates experimental autoimmune neuritis

Fig. 2

Histological examination of cauda equina. A Patchy mononuclear cell infiltration foci are seen on the cauda equina (CE) nerve of rat in the EAN group on day 15 after immunization (p.i.). B CE nerve of rat in the siponimod group on day 15 p.i. Lesser cell infiltration and more LFB-positive area preserved normal myelination than that of rat in the EAN group. C The siponimod group showed statistically significant suppression of demyelination compared with that in the EAN group on day 15 p.i. which is the peak phase of EAN. (Data show mean ± SEM. * p < 0.01, EAN vs. siponimod groups. Statistics analysis using Mann–Whitney U-test.). However, there was no statistically significant difference on days 9, 12, 21, and 28 p.i.

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