Fig. 5

Sequential change of mRNA expression of the molecules related to demyelination, repair program, and remyelination during peripheral nerve injury in cauda equina. The sequential changes in Erbb2, Egr2, Pou3f2, Mpz, Pmp22, Atf3, c-Jun, Gdnf, Shh, and Cyst1 mRNAs in the cauda equina are shown in the bar graphs. Data for A Erbb2, B Egr2, C Pou3f2, D Mpz, E Pmp22, F Atf3, G Gdnf, H Shh, and I Cyth 1 inCE. Data show mean ± SEM. †p < 0.1: Normal rats vs. EAN, *p < 0.05, **p < 0.01: Normal rats vs. EAN or siponimod groups, #p < 0.05: EAN vs. siponimod groups, Statistics analysis using Mann–Whitney U-test