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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Morinda officinalis oligosaccharides mitigate depression-like behaviors in hypertension rats by regulating Mfn2-mediated mitophagy

Fig. 2

Protective effect of Morinda officinalis oligosaccharides on brain injury in depressive and hypertensive rats. A Histological changes in brain tissues were observed by hematoxylin and eosin staining. Tumor necrosis factor α, interleukin (IL)-1β, and IL-6 levels in serum (B) and brain tissues (C) were determined by enzyme-linked immunosorbent assay. D Immunocytochemistry of glial fibrillary acidic protein in astrocytes. E Death of neurons was tested and pictured by immunostaining for neuronal nuclear protein (green). F Mitochondrial morphology was observed using a transmission electron microscope (n = 8 rats/group). Data are shown as the mean ± standard deviation. *p < 0.05, **p < 0.01, and ***p < 0.001 by one-way analysis of variance followed by Tukey’s post hoc test

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