Fig. 8

Mfn2 downregulation abrogated the effect of Morinda officinalis oligosaccharides on depression-like behaviors in hypertensive rats. The systolic pressure (A), diastolic pressure (B), and the mean arterial pressure (C) of the indicated rats. Sucrose preference test (D), open-field test (E), forced swimming test (F), and tail suspension test (G) of the indicated rats. H Histological changes in brain tissues were observed by hematoxylin and eosin staining. Tumor necrosis factor α, interleukin (IL)-1β, and IL-6 levels in serum (I) and brain tissues (J) were determined by enzyme-linked immunosorbent assay. K Mitochondrial morphology was observed using a transmission electron microscope. L Autophagy-related protein levels, including LC3 and p62, were determined by western blotting (n = 8 rats/group). Data are shown as the mean ± standard deviation. *p < 0.05, **p < 0.01, and ***p < 0.001 by one-way analysis of variance followed by Tukey’s post hoc test