Fig. 7

SND1 mediates the LPS-induced inflammatory response in astrocytes. A Treatment of astrocytes with 500 ng/mL LPS for 3, 12, and 24 h elevated SND1 expression as measured by qPCR. **P < 0.01 by one-way ANOVA. B Two of three siRNAs targeting SND1 successfully knocked down SND1 in astrocytes after transfection. *P < 0.05 and **P < 0.01 by one-way ANOVA. C–G Astrocyte expression levels of CCL2, CXCL1, CCL3, CXCL3, and CXCL10 were elevated by LPS, while 2 different siRNAs reversed these effects. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001 by one-way ANOVA