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Table 1 Characteristics of participants

From: Efficacy and safety of lenalidomide in HIV-associated cryptococcal meningitis patients with persistent intracranial inflammation: an open-label, single-arm, prospective interventional study

Characteristic

 

Age (year)

32.5 (30.5–39.3)

Sex, number (%)

 

 Male

14(100)

 Female

0 (0)

Ethnic group, number (%)

 

 Asian

14 (100)

 Other

0 (0)

 Body mass index (kg/m2)

23.1 (20.2–26.4)

 Time from CM to ART initiation, days

25.5 (18.5–36.5)

 Time from ART initiation to LEN, days

558.0 (314.0–882.3)

 Time from anti antifungal to LEN, days

581.0 (340.5–906.5)

ART regimen, number (%)

 

 2NRTI + 1NNRTI

2 (14.3)

 2NRTI + 1PI

1 (7.1)

 2NRTI + 1 INSTI

11 (78.6)

 CD4 + T-lymphocytes count/µL

151.5 (117.0–342.3)

HIV-RNA, number (%)

 

 < 50 copies/ml

11 (78.6)

 50–200 copies/ml

0

 > 200 copies/ml

3 (22.4)

CD4+ T-lymphocyte count (screen), number (%)

 

 < 200 cells/ul

9 (64.3)

 200–500 cells/ul

5 (35.7)

 > 500 cells/ul

0 (0)

Clinical presentation, number (%)

 

 Fever

4 (28.6)

 Headache

7 (50)

 Altered mentation

4 (28.6)

 Seizures

2 (14.3)

  1. Data are median (IQR) or n (%)
  2. ART: antiretroviral therapy; CM: cryptococcal meningitis; LEN: lenalidomide; NRTI: nucleoside reverse transcriptase inhibitor; NNRTI: non-nucleoside reverse transcriptase inhibitor; INSTI: integrase strand transfer inhibitor; PI: protease inhibitor