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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: α-Synuclein induces prodromal symptoms of Parkinson’s disease via activating TLR2/MyD88/NF-κB pathway in Schwann cells of vagus nerve in a rat model

Fig. 5

Deposition of p-α-synuclein in SCs induces inflammatory responses via activating TLR2/MyD88/NF-κB signaling. A, B Representative confocal images and quantitative analysis of TLR2 in the rat left vagus nerve at 3 months post-injection. Scale bar = 10 μm. n = 6. C, D Representative confocal images and quantitative analysis of IL-1β in the rat left vagus nerve at 3 months post-injection. Scale bar = 10 μm. n = 6. Representative western blot bands (E) and the statistical graph (FJ) of total α-synuclein, p-α-synuclein, MyD88, p-NF-κB p65, and IL-1β in the rat left vagus nerve at 3 months post-injection. The protein levels were normalized to GAPDH and expressed as fold over AAV-EV. n = 4. KM Representative immunohistochemical staining and quantitative analysis of TLR2 in sural nerves of controls and PD patients. Scale bar = 10 μm. n = 6. Data were presented as mean ± SEM. Statistical significance was analyzed using two-way ANOVA followed by Bonferroni’s multiple comparison test in B, D, and FJ, and Student’s test in M. ***P < 0.001, ****P < 0.0001. ns, not significant

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