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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: α-Synuclein induces prodromal symptoms of Parkinson’s disease via activating TLR2/MyD88/NF-κB pathway in Schwann cells of vagus nerve in a rat model

Fig. 6

Silencing of TLR2 expression attenuates p-α-synuclein-induced AutD and vagus nerve lesions. SD rats were subjected to vagal injection with AAV-A53T or AAV-A53T as well as AAV-Cas9-TLR2 and then evaluated with gastrointestinal autonomic function 3 months later. A colonic transit time. B 12 h fecal pellet count and total weight (C). D 12 h fecal water content. E Representative images of intestinal blood flow detected by laser Doppler. F Average intestinal blood flow. G Representative images of the left vagus nerve conduction detected by the electromyography system. H Average vagus nerve conduction velocity. I Average amplitude of vagus nerve compound action potential. J Representative TEM images of the ultrastructure of the left vagus nerve in rats. Scale bar = 5 μm. Classification and counting numbers of non-myelinated axons (K) and myelinated axons (L) in left vagus nerve fibers. AD: n = 12 per group; EL: n = 6 per group. Data were presented as mean ± SEM. Statistical significance was analyzed using Student’s test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. ns, not significant; MA, myelinated axons; NMA, non-myelinated axons; MAA, Myelin anomalous alteration

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