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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4/MyD88/NF-κB pathway in LPC-induced demyelination

Fig. 6

Caspase-1 inhibitor VX765 protects against cognitive impairment in LPC-induced demyelination. A In Morris water maze experiment, escape latency of mice during acquisition test from 5 to 9 dpi was recorded, representative tracks at 9 dpi were displayed. N = 10/group. Two-way ANOVA followed by Tukey’s test. B Statistical analysis of percent time spent in the target quadrant during the probe trial among groups. And representative tracks in different groups were displayed. N = 10/group. One-way ANOVA with Tukey’s post hoc test. C Novel object recognition test was performed from 8 to 10 dpi. DI was calculated to compare the preference for novel objects in different groups. N = 5–6, one-way ANOVA with Bonferroni’s test was applied. *P < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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Journal of Neuroinflammation

ISSN: 1742-2094