Fig. 8From: Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4/MyD88/NF-κB pathway in LPC-induced demyelinationThe schematic diagram illustrating how Tregs protect against myelin injury by alleviating pyroptosis and neuroinflammation in demyelination induced by LPC. LPC-demyelination induces pyroptosis in microglia and inflammatory responses in CNS. Mechanically, Tregs alleviate pyroptosis by inhibiting TLR4/MyD88 and downstream phosphorylation of NF-κB, which inhibit NLRP3 inflammasome and subsequent pyroptosis. In addition, Tregs could regulate neuroinflammation by suppressing inflammatory cytokines including TNF-α, IL-6, IFN-γ and IL-1βBack to article page