Fig. 1

Astrocytes engulf and accumulate Aβ. Human iPSC derived astrocytes were exposed to sonicated Aβ fibrils for 7 days and the cells were analyzed 0 days (7d), 6 days (7d + 6d) or 12 days (7d + 12d) after exposure (A). Aβ fibrils were visualized with TEM before (B) and after sonication (C). Quantification of the HiLyteFluor555 signal, revealed that there was a slight rise in Aβ signal at 7d + 6d followed by a decrease at 7d + 12d (D). Aβ inclusions were found inside the astrocytes at all three time points (E). Scale bar: E = 20 µm