Fig. 1

Antiretroviral therapy entecavir reversed chronic stress-induced negative emotional behaviors. A Schematic representation. B Diagram showing the daily bodyweight, as well as statistical analysis of bodyweight during a 6-w period for each group. One-way ANOVA with Tukey's post hoc test, **P < 0.01, compared with CONT; n = 12. C Heat maps and statistical analysis of central time% and total distance in OF test for each group. One-way ANOVA with Tukey's post hoc test, ***P < 0.001, compared with CONT; ##P < 0.01, ###P < 0.001, compared with SUS-PBS; n = 12. D Heat maps and statistical analysis of open arms time% and open arms entries% in EPM test for each group. One-way ANOVA with Tukey's post hoc test, ***P < 0.001, compared with CONT; ##P < 0.01, ###P < 0.001, compared with SUS-PBS; n = 12. E Track maps and statistical analysis of recognition index of investigations and time in NOR test for each group. One-way ANOVA with Tukey's post hoc test, ***P < 0.001, compared with CONT; ##P < 0.01, ###P < 0.001, compared with SUS-PBS; n = 12. F Statistical analysis of sucrose preference% in SP test for each group. One-way ANOVA with Tukey's post hoc test, ***P < 0.001, compared with CONT; ##P < 0.01, ###P < 0.001, compared with SUS-PBS; n = 12. G Statistical analysis of immobility time% in FS test for each group. One-way ANOVA with Tukey's post hoc test, ***P < 0.001, compared with CONT; ###P < 0.001, compared with SUS-PBS; n = 12. H Statistical analysis of immobility time% in TS test for each group. One-way ANOVA with Tukey's post hoc test, ***P < 0.001, compared with CONT; ###P < 0.001, compared with SUS-PBS; n = 12