Fig. 5

Microglial BMAL1 deficiency decreases synaptic engulfment in aged mice. A Representative images of IBA1 + /CD68 + cell engulfment of PSD95 + particles in microglia in aged CD11b^cre and CD11b^cre;Bmal1^lox/lox mice. Scale bar, 2 µm. B Orthogonal views and rotated 3D projection of PSD95 + particles in IBA + /CD68 + microglia from aged CD11b^cre and CD11b^cre;Bmal1^lox/lox mice. C Pearson’s coefficient of colocalization of PSD95 and CD68 in IBA1 + cells (n = 6/group) mice. Data are represented as the mean ± SEM. P-values were calculated using two-tailed Student’s t-test