Fig. 5

THC administration increased pipecolate, endocannabinoids, endocannabinoid-like, glycerophospholipid, and indole-3-propionate levels. Statistical summary (A) and PCA plot (B) of metabolites detected in plasma of uninfected and SIV-infected RMs administered VEH or THC. Plasma levels of pipecolate (C), endocannabinoids (D), endocannabinoid-like (E–G), glycerophospholipid (K, L), kynurenine–tryptophan ratios and indole-3-propionate (N, O), creatinine (S), and 3-hydroxyhippurate (T) in VEH/SIV (n = 6) or THC/SIV (n = 5) RMs at 5 MPI and uninfected control RMs (n = 16). Red and green arrows and numbers (A) represent increased and decreased metabolites, respectively. Pathway figures show endocannabinoids (H–J), phospholipids (M), and tryptophan metabolites (P–R) detected in plasma of VEH/SIV or THC/SIV relative to uninfected control RMs or THC/SIV relative to VEH/SIV RMs. Red and blue circles represent significantly increased and decreased metabolites, respectively. Light blue and pink circles represent increased and decreased metabolites, respectively, with a p-value between 0.05 and 0.09. Size of the circle indicates relative abundance. Open circles represent outliers for that particular metabolite. A p-value of < 0.05 was considered significant