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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Cannabinoids modulate the microbiota–gut–brain axis in HIV/SIV infection by reducing neuroinflammation and dysbiosis while concurrently elevating endocannabinoid and indole-3-propionate levels

Fig. 6

THC administration significantly increased relative abundance of Firmicutes, Clostridia, Clostridiales in colon of SIV-infected RMs. The Beta-diversity (PCA) (A), taxonomy cluster (C, H) and heat map (D, I) of top 21 colon bacterial class (C, D) and bacterial order (H, I) before and at 6 MPI in VEH or THC-treated chronically SIV-infected RMs. Dot plots show relative abundance of phylum Firmicutes (B) and class Clostridia (E), Negativicutes (F), and Gammaproteobacteria (G) in colon of VEH/SIV and THC/SIV at 6 MPI compared to uninfected control RMs. Relative abundance of order Clostridiales (J), Bifidobacteriales (K), Firmicutes_noname (L), and Gammaproteobacteria_unclassifed (M) in colon of VEH/SIV and THC/SIV relative to uninfected control RMs. CCCN–uninfected controls, VEHC6M-–VEH/SIV 6 MPI, THCC6M-–THC/SIV 6 MPI, MPI–months post-SIV infection. A p-value of < 0.05 was considered significant

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Journal of Neuroinflammation

ISSN: 1742-2094