Skip to main content
Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Cannabinoids modulate the microbiota–gut–brain axis in HIV/SIV infection by reducing neuroinflammation and dysbiosis while concurrently elevating endocannabinoid and indole-3-propionate levels

Fig. 8

THC administration modulated relative abundance of IPA and SCFA-producing colonic species of SIV-infected RMs. Dot plots show relative abundance of Indole-3-propionate (IPA) [Clostridium botulinum (A), Clostridium paraputrificum (A), Clostridium cadaveris (B), and Clostridium sporogenes (C)] and short chain fatty acid (SCFA) [Faecalibacterium prausnitzii (D) and Butyricicoccus pullicaecorum (E)] producers, and the dysbiotic species Enterococcus faecalis (F) in colon of THC/SIV and VEH/SIV at 6 MPI relative to uninfected control RMs. Heat maps show relative abundance of commensal Clostridia (G–I), Lactobacillus (J–L) and Bifidobacteria species (M–O) in colon of THC/SIV (G, J, M), VEH/SIV (H, K, N) compared to uninfected control RMs and in THC/SIV (I, L, O) relative to VEH/SIV RMs at 6 MPI. CCCN–uninfected controls, VEHC6M–VEH/SIV 6 MPI, THCC6M–THC/SIV 6 MPI, MPI–months post-SIV infection. A p-value of < 0.05 was considered significant

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094