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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Depletion and activation of microglia impact metabolic connectivity of the mouse brain

Fig. 2

Metabolic connectivity changes in WT mice upon microglial depletion at two different ages. A Study overview: two groups of PLX5622 treated WT mice were compared with two groups of age-matched control WT mice. Treated mice received the CSF1R inhibitor for a duration of 5–7 weeks at either 6 months or 9 months of age. The follow-up PET scan was performed under treatment. Single boxes indicate inter-regional Z’. All absolute hot-scaled ICCs are presented upon a 3D mouse brain template. B, D Single matrix elements indicate the difference in inter-regional Z’ upon treatment/vehicle. C, E Bar graphs depict the reduction of average cortical Z’ upon microglia depletion. Error bars represent the standard error of the mean. Significance was obtained by a paired t test

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