Fig. 3

Comparison of metabolic connectivity and FDG–PET SUV in Grn^−/−, Trem2^−/−, Grn^−/−/Trem2^−/− and WT mice. A–D Hot scaled FDG–PET images of 10.6 ± 1.5-month-old mice depict glucose uptake in axial and coronal images upon a MRI template. Single matrix elements indicate inter-regional Z’. Subcortical regions are highlighted with black lines, cortical regions with black dots. Connections between Hippocampus and Cortex as well as Subcortex and Cortex are highlighted with white dots and white lines. All absolute hot scaled ICCs are presented upon a 3D mouse brain template. E–H Bar graphs indicate mean Z’ of the absolute values for each highlighted brain region. Error bars represent the standard error of the mean. Statistics were derived from one-way repeated measures ANOVA with Tukey’s multiple comparisons test