Table 1 Summary of analyzed data
From: Depletion and activation of microglia impact metabolic connectivity of the mouse brain
Mouse model | Age (months) | Animal (n) | Scanner | Sex (f/m) | Weight (g) | Injected dose (MBq) |
|---|---|---|---|---|---|---|
WT with PLX5622 treatment | 6–7 | 9 | PET | 4/5 | 29.7 ± 4.6 | 14.0 ± 1.9 |
|  | 9–10 | 8 | PET | 8/0 | 24.3 ± 3.3 | 14.2 ± 2.2 |
WT with placebo treatment (control) | 6–7 | 14 | PET | 10/4 | 25.4 ± 4.0 | 14.6 ± 2.0 |
|  | 9–10 | 13 | PET | 11/2 | 24.7 ± 3.1 | 14.0 ± 2.2 |
Grn−/− | 9–12 | 10 | PET–MRI | 10/0 | 26.9 ± 2.6 | 15.5 ± 2.5 |
Trem2−/− | 9–12 | 13 | PET–MRI | 13/0 | 28.4 ± 4.7 | 15.2 ± 2.5 |
Grn−/−/Trem2−/− | 9–12 | 10 | PET–MRI | 10/0 | 26.6 ± 1.3 | 17.3 ± 1.5 |
WT | 9–12 | 17 | PET–MRI | 17/0 | 27.2 ± 3.1 | 14.1 ± 2.2 |