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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Human umbilical cord-derived mesenchymal stem cell transplantation supplemented with curcumin improves the outcomes of ischemic stroke via AKT/GSK-3β/β-TrCP/Nrf2 axis

Fig. 7

Combined curcumin and hUC-MSCs treatment suppressed ROS generation and exerted antioxidative and anti-inflammatory effects through AKT/GSK-3β/β-TrCP/Nrf2 pathway in vitro. A Confocal microscopy images showing relative intracellular ROS levels in microglia. B, C Flow cytometric curves (B) and quantification (C) showing DCF-DA fluorescence intensities in microglia. D–I Quantitative analysis of the expression of pro-inflammatory cytokines IL-1β (D), IL-6 (E), TNF-α (F) and anti-inflammatory cytokines IL-4 (G), IL-10 (H), TGFβ1 (I) in microglia. J–L The expression levels of oxidative damage-related biomarkers of MDA (J), SOD (K), and GPx (L) in microglia. Cur curcumin, scale bars = 20 μm; N = 5; N.S. no significant difference, *P < 0.05, **P < 0.01, ***P < 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094