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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Human umbilical cord-derived mesenchymal stem cell transplantation supplemented with curcumin improves the outcomes of ischemic stroke via AKT/GSK-3β/β-TrCP/Nrf2 axis

Fig. 9

Combined curcumin-hUC-MSC treatment inhibited the neuronal apoptosis by paracrine path via AKT/GSK-3β/β-TrCP/Nrf2 axis in vitro. Collected the supernatant with different treatments in Nrf2 +/+ or Nrf2 −/− microglia to cultivate the OGD neurons. (A-B) Representative images (A) and quantification (B) of immunofluorescence analysis of neuronal apoptosis. The neuron-specific marker NeuN (red), the apoptosis marker CC3 (green), and nuclei (blue). C, D Flow cytometric analysis (C) and the quantification (D) for the neuronal apoptosis. Cur: curcumin, scale bars = 20 μm; N = 5; N.S. no significant difference, **P < 0.01, ***P < 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094