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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: A short peptide exerts neuroprotective effects on cerebral ischemia–reperfusion injury by reducing inflammation via the miR-6328/IKKβ/NF-κB axis

Fig. 7

MiRNA sequencing analysis of cerebral cortex tissue in rats (n = 3). A In total, 59 miRNAs showed significant differential expression between the sham and I/R groups, with down-regulated miRNAs in green and up-regulated miRNAs in red. B In total, 55 miRNAs showed significant differential expression between the I/R and 10 nmol/kg NP1 groups, with down-regulated miRNAs in green and up-regulated miRNAs in red. C Venn diagram of number of differential miRNAs obtained after pairwise comparison of three groups, overlap is number of miRNAs simultaneously present in two or three groups. D Top 10 most significant visualizations after KEGG enrichment analysis of target genes of 19 differentially expressed miRNAs after intersection. E Venn diagram of number of target genes in MAPK, PI3K/Akt, and neurotrophin signaling pathways, overlap is number of target genes simultaneously present in two or three pathways. F Prediction of target proteins of significantly up-regulated miRNAs and their interactions. G. Prediction of binding site of miR-6328 to IKKβ

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Journal of Neuroinflammation

ISSN: 1742-2094