Fig. 9

Activin-A is essential for PE-associated repair of white matter integrity and axonal remyelination. A Representative LFB staining images of corpus callosum and striatum of rats in different groups. B Location of the brain tissues used for staining or western blotting. C Relative optical densities in corpus callosum and striatum of rats in different groups. D Representative TEM images of myelin in ipsilateral corpus callosum and striatum. Red arrows refer to myelin thickness, bar = 1um; E Scatter plots of g-ratio in each group. F G-ratio of myelinated axons for each group of rats (n = 3 rats/group). G Representative images of BCAS1⁺ oligodendrocytes in various groups (× 40 objective, zoomed in 3). H Representative images of Oligo2⁺ oligodendrocytes in various groups (× 40 objective, zoomed in 3). I Comparison of the number of BCAS1⁺ oligodendrocytes for each group. J Comparison of the number of Oligo2⁺ oligodendrocytes for each group. One-way ANOVA and Bonferroni post hoc tests. Data are expressed as mean ± SD for n = 6. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001