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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Exogenous monocyte myeloid-derived suppressor cells ameliorate immune imbalance, neuroinflammation and cognitive impairment in 5xFAD mice infected with Porphyromonas gingivalis

Fig. 3

Pg reduced the proportion and immunosuppressive function of mMDSCs in vitro. Representative FACS plots of gating strategy for MDSCs (A) and two subpopulations (C) in BL, SP, and bone marrow (BM) of 5xFAD mice with or without Pg treatment. The proportions of MDSCs (B), mMDSCs (D) and gMDSCs (E) were presented. F Representative FACS plots of proliferation of MLN cells (mainly T cells) labeled with eFluor 450 and co-cultured with BM cells for 48 h. G Statistical results of F. H Representative FACS plots of eFluor 450 labelled CD4+ T cells sorted from MLN cells and co-cultured with sorted mMDSCs and gMDSCs for 48 h. I Statistical results of H. Data are presented as means ± SEM. * p < 0.05; ** p < 0.01; *** p < 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094