Fig. 4

Exogenous mMDSCs improved behavioral function of 5xFAD mice infected with Pg. A Experiment design of oral Pg administration and intravenous mMDSCs injection in 5XFAD mice. B Representative FACS plots of gating strategy for mMDSCs sorting with BM cells and the sorting efficiency. C Escape latencies of three groups of mice in the spatial acquisition trial of the MWM. DTimes of mice crossing over the platform area in the probe trial of the MWM. E, F Time and travelling distance of mice in the TQ in the probe trial of the MWM. G Distance travelled to the platform area in the probe trial of the MWM. H Average swimming speed of mice in the probe trial of the MWM. I Total distance travelled in the open field test (OFT). J Moving distance in the central area in the OFT. K Time spent in the central area in the OFT. L Representative traces of each group in the MWM and OFT. Data are presented as means ± SEM. * p < 0.05; ** p < 0.01