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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Berberine ameliorates depression-like behaviors in mice via inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing neuroplasticity disruption

Fig. 6

Berberine increases hippocampal adult neurogenesis induced by CORT. a Representation of the Golgi-Cox staining of hippocampal adult neuron. b Spine density results from Golgi staining (One-way ANOVA, F (3, 8) = 17.10, P = 0.0008; Dunnett’s multple comparisons test, CORT vs. Control, P = 0.0005, CORT vs. BBR100, P = 0.0112, CORT vs. BBR200, P = 0.0010, n = 3 in each group). c Proportion of mushroom spines (One-way ANOVA, F (3, 8) = 6.068, P < 0.0001; Dunnett’s multple comparisons test, CORT vs. Control, P = 0.0117, CORT vs. BBR200, P = 0.0432, n = 3 in each group). d Proportion of thin spines (One-way ANOVA, F (3, 8) = 52.74, P < 0.0001; Dunnett’s multple comparisons test, CORT vs. Control, P = 0.0001, CORT vs. BBR100, P = 0.0054, CORT vs. BBR200, P < 0.0001, n = 3 in each group). e Representative electron micrographs showing the synaptic structure and postsynaptic densities on neurons. Scar bar, 200 µm. f Depth of post synaptic dendrites (One-way ANOVA, F (3, 8) = 38.93, P < 0.0001; Dunnett’s multple comparisons test, CORT vs. Control, P < 0.0001, CORT vs. BBR100, P = 0.0033, CORT vs. BBR200, P = 0.0001, n = 3 in each group). g Length of post synaptic dendrites (One-way ANOVA, F (3, 8) = 220.0, P < 0.0001; Dunnett’s multple comparisons test, all comparisons P < 0.0001, n = 3 in each group). Bar graphs show the mean ± SEM; *P < 0.05, **P < 0.01, and ***P < 0.001. CORT corticosterone, BBR berberine, ANOVA analysis of variance

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