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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Microglia specific deletion of miR-155 in Alzheimer’s disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures

Fig. 2

Anti-inflammatory gene expression is upregulated in microglia after microglia-specific knock-out of miR-155 in vivo. qPCR analysis of total RNA extracted form ex vivo-FACS sorted microglia (CX3CR1YFP+/CD45int cells). In the APP/PS1 model A) cMaf B) Csf1r C) Inpp5d (SHIP1) D) Socs1 and E) Tfeb are upregulated in microglia in vivo after miR-155 CKO. We observed that Csf1r was not significantly upregulated in microglia after miR-155 CKO in the APP/PS1 mouse model of AD (Stats: two-way ANOVA with multiple comparisons, Tukey’s post hoc correction (** = p < 0.005, *** = p < 0.0005)

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