Skip to main content
Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Microglia specific deletion of miR-155 in Alzheimer’s disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures

Fig. 3

miR-155 deletion from microglia in adult APP/PS1 mice leads to a reduction in insoluble Aβ1–42 and total plaque area. A Analysis of the insoluble protein fractions by Luminex detected decreased levels of Aβ1–42 in APP/PS1 microglia miR-155 conditional knock-out mice (APP/PS1 MG miR-155 CKO) compared to non-deleted controls (APP/PS1) (two-tailed unpaired t-test, * = p < 0.05), B while there was no detectable change in Aβ1–40 levels. C and D Representative images of immunostaining for Aβ-plaques (6E10) in APP/PS1 and APP/PS1 miR-155 MG CKO brains. E Aβ-plaque area quantification based on 6E10 immunostaining in CA1 and CA3 (two-tailed unpaired t-test, * = p < 0.05)

Back to article page