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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Microglia specific deletion of miR-155 in Alzheimer’s disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures

Fig. 6

Microglia-specific inducible knock-out of miR-155 in leads to aberrant cortical excitability in the 5xFAD mouse model of AD. A Experimental and control genotypes and groups. B Experimental design summary. Mice were implanted with ECoG and EMG electrodes at 7 weeks of age, and after a baseline recording, miR-155 knock-out was induced at 8 weeks. Continuous recordings were made for 2 weeks. Representative trace of C baseline and D high-amplitude, synchronous spiking in the EEG. E %epochs (hours) containing inter-ictal spikes, high-amplitude, synchronous spiking in the EEG were increased after miR-155 deletion in microglia in 5xFAD mice (Mixed Linear Model, p = 0.027, R2 = 0.1312)

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