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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: IL-1β and TNF-α play an important role in modulating the risk of periodontitis and Alzheimer’s disease

Fig. 5

Bacterial-induced periodontitis increased phosphorylated tau proteins immunoreactivity in the brains of 3 × Tg-AD mice. a Representative images of immunofluorescence staining for phosphorylated tau Ser396 (green) and DAPI (blue) in the cortex, sub-regions of the hippocampus, and thalamus of 3 × Tg-AD mice in each group. b Representative images of immunofluorescence staining for phosphorylated tau Ser404 (green) and DAPI (blue) in the cortex, sub-regions of the hippocampus, and thalamus of 3 × Tg-AD mice in each group. c, d Quantification of (c) phosphorylated tau Ser396 and (d) phosphorylated tau Ser404 immunofluorescence intensity in the cortex, sub-regions of the hippocampus, and thalamus of 3 × Tg-AD mice in each group. Data are presented as mean ± SEM (n = 5–7). Statistical analysis was done using unpaired t test. *p < 0.05, **p < 0.01

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