Fig. 4

β-2 but not a β-1 AR agonist protects dopaminergic neurons in the SN from hα-SYN-mediated neurotoxicity. A Representative images of the SN showing dopaminergic neurons degeneration in the injected SN (TH, white) and B quantification of TH+ dopaminergic neurons in coronal sections of the SN 4 weeks after rAAV2–hα-SYN injection in WT mice treated daily with saline, Xamoterol or Clenbuterol. Data are shown as mean values ± SEM, each dot represents one mouse, NS: not significant, *p < 0.05; ***p < 0.001. One-way ANOVA followed by Tukey post hoc test. Scale bar = 500 µm